{"id":2776316,"date":"2021-03-15T06:45:00","date_gmt":"2021-03-15T06:45:00","guid":{"rendered":"https:\/\/vip2-msd.com\/merckcom-migrated\/news\/gilead-and-merck-announce-agreement-to-jointly-develop-and-commercialize-long-acting-investigational-treatment-combinations-of-lenacapavir-and-islatravir-in-hiv\/"},"modified":"2025-03-07T23:38:58","modified_gmt":"2025-03-08T04:38:58","slug":"gilead-and-merck-announce-agreement-to-jointly-develop-and-commercialize-long-acting-investigational-treatment-combinations-of-lenacapavir-and-islatravir-in-hiv-2","status":"publish","type":"news_item","link":"https:\/\/vip2-msd.com\/merckcom-migrated\/news\/gilead-and-merck-announce-agreement-to-jointly-develop-and-commercialize-long-acting-investigational-treatment-combinations-of-lenacapavir-and-islatravir-in-hiv-2\/","title":{"rendered":"Gilead and Merck Announce Agreement to Jointly Develop and Commercialize Long-Acting, Investigational Treatment Combinations of Lenacapavir and Islatravir in HIV"},"content":{"rendered":"<p style=\"text-align: center\"><strong>Collaboration to Focus on Oral and Injectable Formulations of Lenacapavir and<br \/>\n        Islatravir <\/strong><\/p>\n<p style=\"text-align: center\"><strong>Agreement Brings Together Potentially Complementary Medicines in Late-Stage<br \/>\n        Development with the Goal to Provide Innovative, Long-Acting Treatments in HIV <\/strong><\/p>\n<p>Foster City, Calif. and Kenilworth N.J. \u2013 March 15, 2021 \u2013 Gilead Sciences, Inc. (Nasdaq: GILD) and Merck (NYSE:<br \/>\n    MRK), known as MSD outside the United States and Canada, today announced that they have entered into an agreement to<br \/>\n    co-develop and co-commercialize long-acting treatments in HIV that combine Gilead\u2019s investigational capsid<br \/>\n    inhibitor, lenacapavir, and Merck\u2019s investigational nucleoside reverse transcriptase translocation inhibitor,<br \/>\n    islatravir, into a two-drug regimen with the potential to provide new, meaningful treatment options for people<br \/>\n    living with HIV.<\/p>\n<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Islatravir and lenacapavir are both potentially<br \/>\n    first-in-class medicines in late-stage clinical trials, with significant clinical data generated to date. Both<br \/>\n    medicines have long half-lives and have demonstrated activity at low dosages in clinical studies, which support<br \/>\n    development as an investigational combination regimen with long-acting formulations, both oral and injectable.<\/p>\n<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The first clinical studies of the oral combination<br \/>\n    are expected to begin in the second half of 2021. Under the terms of the agreement, Gilead and Merck will work as<br \/>\n    partners, sharing operational responsibilities, as well as development, commercialization and marketing costs, and<br \/>\n    any future revenues.<\/p>\n<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Merck and Gilead seek to build on their legacies<br \/>\n    of transforming HIV care by focusing on long-acting therapies, which may represent a meaningful innovation in HIV<br \/>\n    drug development. While daily, single-tablet regimens are available for people living with HIV, options that would<br \/>\n    allow for less frequent, oral dosing or infrequent injections rather than daily dosing have the potential to address<br \/>\n    preference considerations, as well as issues associated with adherence and privacy.<\/p>\n<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; As the field of HIV treatment evolves, long-acting<br \/>\n    therapies may provide additional options for people living with HIV and their physicians that will help continue to<br \/>\n    put the needs of individuals at the center of their own care.<\/p>\n<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;\u201cAt Merck, we are resolute in our commitment to<br \/>\n    advancing the care of people living with HIV as part of our mission to save and improve lives,\u201d said Kenneth C.<br \/>\n    Frazier, chairman and chief executive officer, Merck. \u201cThis collaboration with Gilead brings together two companies<br \/>\n    dedicated to the fight against HIV to develop potential new long-acting treatment options, and is an important step<br \/>\n    forward in our strategy to harness the full potential of islatravir for the treatment of HIV.\u201d<\/p>\n<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;\u201cThrough this agreement with Merck, Gilead is<br \/>\n    reinforcing its long-term role in transforming HIV care,\u201d said Daniel O\u2019Day, chairman and chief executive officer,<br \/>\n    Gilead Sciences. \u201cOur work in HIV over the past decades has been shaped by listening to people living with HIV and<br \/>\n    the physicians who treat them. Now we are taking the same approach with long-acting therapies, combining the most<br \/>\n    advanced science from both companies to accelerate progress.\u201d<\/p>\n<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Lenacapavir and islatravir, alone and in<br \/>\n    combination, are investigational and not approved anywhere globally. Their safety and efficacy have not yet been<br \/>\n    established.<\/p>\n<p><strong><br \/>Terms of the Collaboration<\/strong><\/p>\n<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Under the terms of the agreement, Gilead and Merck will<br \/>\n    co-develop and co-commercialize long-acting products to treat people living with HIV that combine Gilead\u2019s<br \/>\n    proprietary investigational capsid inhibitor, lenacapavir, and Merck\u2019s proprietary investigational nucleoside<br \/>\n    reverse transcriptase translocation inhibitor, islatravir. The collaboration will initially focus on long-acting<br \/>\n    oral formulations and long-acting injectable formulations of these combination products, with other formulations<br \/>\n    potentially added to the collaboration as mutually agreed.<\/p>\n<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Across the oral and injectable formulation<br \/>\n    programs, Gilead and Merck will share global development and commercialization costs 60%\/40%, respectively. For<br \/>\n    long-acting oral products, Gilead will lead commercialization in the U.S. and Merck will lead commercialization in<br \/>\n    the EU and rest of the world. For long-acting injectable products, Merck will lead commercialization in the U.S. and<br \/>\n    Gilead will lead commercialization in the EU and rest of the world.<\/p>\n<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Gilead and Merck will co-promote in the U.S. and<br \/>\n    other certain major markets. Merck and Gilead will share global product revenues equally until product revenues<br \/>\n    surpass certain pre-agreed per formulation revenue tiers. Upon passing $2 billion a year in net product sales for<br \/>\n    the oral combination, the revenue split will adjust to 65% Gilead and 35% Merck for any revenues above the<br \/>\n    threshold. Upon passing $3.5 billion a year in net product sales for the injectable combination, the revenue split<br \/>\n    will adjust to 65% Gilead and 35% Merck for any revenues above the threshold.&nbsp;<\/p>\n<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Beyond the potential combinations of lenacapavir<br \/>\n    and islatravir, Gilead will have the option to license certain of Merck\u2019s investigational oral integrase inhibitors<br \/>\n    to develop in combination with lenacapavir. Reciprocally, Merck will have the option to license certain of Gilead\u2019s<br \/>\n    investigational oral integrase inhibitors to develop in combination with islatravir. Each company may exercise its<br \/>\n    option for an investigational oral integrase inhibitor of the other company following completion of the first Phase<br \/>\n    1 clinical trial of that integrase inhibitor. Upon exercise of an option, the companies will split development cost<br \/>\n    and revenues, unless the non-exercising company decides to opt-out. Both companies currently have oral once-weekly<br \/>\n    integrase inhibitors in preclinical development.<\/p>\n<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Cowen &amp; Company LLC is acting as financial<br \/>\n    advisor to Gilead. Hogan Lovells and White &amp; Case, LLP are serving as legal counsel to Gilead. Morgan, Lewis<br \/>\n    &amp; Bockius and Gibson Dunn are serving as legal counsel to Merck.<\/p>\n<p><strong>About Islatravir (MK-8591)<\/strong><\/p>\n<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Islatravir (formerly MK-8591) is Merck\u2019s<br \/>\n    investigational nucleoside reverse transcriptase translocation inhibitor (NRTTI) that exhibits both translocation<br \/>\n    inhibition (which prevents nucleotide binding and incorporation to the DNA chain, resulting in immediate chain<br \/>\n    termination) and delayed chain termination (which prevents nucleotide incorporation even in the event of<br \/>\n    translocation). Islatravir is currently being evaluated for the treatment of HIV-1 infection in combination with<br \/>\n    other antiretrovirals, including the ILLUMINATE clinical trials program for oral, once-daily treatment. Islatravir<br \/>\n    is also being studied for pre-exposure prophylaxis (PrEP) of HIV-1 infection as a single agent across a variety of<br \/>\n    formulations, including the IMPOWER clinical trials evaluating an oral once-monthly regimen. In 2012, Merck licensed<br \/>\n    islatravir (4\u2019-ethynyl-2-fluoro-2\u2019-deoxyadenosine or EFdA) from the Yamasa Corporation based in Choshi, Japan.<\/p>\n<p><strong>About Lenacapavir<\/strong><\/p>\n<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Lenacapavir is a novel investigational capsid<br \/>\n    inhibitor that interrupts the activity of HIV capsid, a protein that surrounds and protects the virus\u2019 genetic<br \/>\n    material and essential enzymes. In <em>in vitro<\/em> studies, lenacapavir interrupts multiple distinct stages of the<br \/>\n    viral lifecycle, potentially preventing the virus from becoming infectious and gaining access to uninfected cells.\n<\/p>\n<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; The safety, efficacy and dosing of lenacapavir are<br \/>\n    being evaluated in multiple ongoing clinical studies. Data presented at AIDS 2020 from the ongoing Phase 1 study<br \/>\n    support subcutaneous every six-month administration of lenacapavir for both HIV treatment and prevention studies.<br \/>\n    During IDWeek 2020, the company announced it would be evaluating the use of lenacapavir among cisgender women as an<br \/>\n    injectable PrEP option administered every six months. An additional lenacapavir for PrEP study in men who have sex<br \/>\n    with men and persons of trans experience is planned. Both studies are expected to begin in 2021.<\/p>\n<p><strong>About Gilead Sciences<\/strong><\/p>\n<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Gilead Sciences, Inc. is a biopharmaceutical<br \/>\n    company that has pursued and achieved breakthroughs in medicine for more than three decades, with the goal of<br \/>\n    creating a healthier world for all people. The company is committed to advancing innovative medicines to prevent and<br \/>\n    treat life-threatening diseases, including HIV, viral hepatitis and cancer. Gilead operates in more than 35<br \/>\n    countries worldwide, with headquarters in Foster City, California.<\/p>\n<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; For more than 30 years, Gilead has been a leading<br \/>\n    innovator in the field of HIV, driving advances in treatment, prevention, testing and linkage to care, and cure<br \/>\n    research. Today, millions of people living with HIV globally receive antiretroviral therapy provided by Gilead or<br \/>\n    one of the company\u2019s manufacturing partners.<\/p>\n<p><strong>About Merck<\/strong><\/p>\n<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; For more than 130 years, Merck, known as MSD<br \/>\n    outside of the United States and Canada, has been inventing for life, bringing forward medicines and vaccines for<br \/>\n    many of the world\u2019s most challenging diseases in pursuit of our mission to save and improve lives. We demonstrate<br \/>\n    our commitment to patients and population health by increasing access to health care through far-reaching policies,<br \/>\n    programs and partnerships. Today, Merck continues to be at the forefront of research to prevent and treat diseases<br \/>\n    that threaten people and animals \u2013 including cancer, infectious diseases such as HIV and Ebola, and emerging animal<br \/>\n    diseases \u2013 as we aspire to be the premier research-intensive biopharmaceutical company in the world. For more<br \/>\n    information, visit <a href=\"http:\/\/vip2-msd.com\/merckcom-migrated\">vip2-msd.com\/merckcom-migrated<\/a> and connect with us on <a href=\"https:\/\/twitter.com\/Merck\">Twitter<\/a>, <a href=\"https:\/\/www.facebook.com\/MerckInvents\/\">Facebook<\/a>, <a href=\"https:\/\/www.instagram.com\/merck\/\">Instagram<\/a>, <a href=\"http:\/\/www.youtube.com\/Merck\">YouTube<\/a> and <a href=\"https:\/\/www.linkedin.com\/company\/merck\">LinkedIn<\/a>.<\/p>\n<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; For more than 35 years, Merck has been committed<br \/>\n    to scientific research and discovery in HIV, and we continue to be driven by the conviction that more medical<br \/>\n    advances are still to come. Our focus is on pursuing research that addresses unmet medical needs and helps people<br \/>\n    living with HIV and their communities. We remain committed to working hand-in-hand with our partners in the global<br \/>\n    HIV community to address the complex challenges that hinder continued progress toward ending the epidemic.<\/p>\n<p><strong>Gilead Forward-Looking Statements<\/strong><\/p>\n<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; This press release includes forward-looking<br \/>\n    statements within the meaning of the Private Securities Litigation Reform Act of 1995 that are subject to risks,<br \/>\n    uncertainties and other factors, including the risk that Gilead may not realize any anticipated benefits from this<br \/>\n    collaboration; difficulties or unanticipated expenses in connection with the collaboration and the potential effects<br \/>\n    on Gilead\u2019s revenues and earnings; the ability of the companies to initiate and complete clinical trials involving<br \/>\n    the combinations of lenacapavir and islatravir and other investigational oral integrase inhibitors in the<br \/>\n    anticipated timelines or at all; the possibility of unfavorable results from ongoing and additional clinical trials,<br \/>\n    including other Gilead trials involving lenacapavir; the ability of the companies to successfully co-develop and<br \/>\n    co-commercialize long-acting HIV treatments; uncertainties relating to regulatory applications and related filing<br \/>\n    and approval timelines, including the risk that regulatory authorities may not approve such applications in the<br \/>\n    anticipated timelines or at all, and any marketing approvals, if granted, may have significant limitations on its<br \/>\n    use; and the possibility that the companies may make a strategic decision to terminate this collaboration. These<br \/>\n    risks, uncertainties and other factors could cause actual results to differ materially from those referred to in the<br \/>\n    forward-looking statements. The reader is cautioned not to rely on these forward-looking statements. These and other<br \/>\n    risks are described in detail in Gilead\u2019s Annual Report on Form 10-K for the year ended December 31, 2020, as filed<br \/>\n    with the U.S. Securities and Exchange Commission. All forward-looking statements are based on information currently<br \/>\n    available to Gilead, and Gilead assumes no obligation to update any such forward-looking statements.<\/p>\n<p><strong>Forward-Looking Statement of Merck &amp; Co., Inc., Kenilworth, N.J., USA<\/strong><\/p>\n<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; This news release of Merck &amp; Co., Inc.,<br \/>\n    Kenilworth, N.J., USA (the \u201ccompany\u201d) includes \u201cforward-looking statements\u201d within the meaning of the safe harbor<br \/>\n    provisions of the U.S. Private Securities Litigation Reform Act of 1995. These statements are based upon the current<br \/>\n    beliefs and expectations of the company\u2019s management and are subject to significant risks and uncertainties. There<br \/>\n    can be no guarantees with respect to pipeline products that the products will receive the necessary regulatory<br \/>\n    approvals or that they will prove to be commercially successful<strong>.<\/strong> If underlying assumptions prove<br \/>\n    inaccurate or risks or uncertainties materialize, actual results may differ materially from those set forth in the<br \/>\n    forward-looking statements.<\/p>\n<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Risks and uncertainties include but are not<br \/>\n    limited to, general industry conditions and competition; general economic factors, including interest rate and<br \/>\n    currency exchange rate fluctuations; the impact of the global outbreak of novel coronavirus disease (COVID-19); the<br \/>\n    impact of pharmaceutical industry regulation and health care legislation in the United States and internationally;<br \/>\n    global trends toward health care cost containment; technological advances, new products and patents attained by<br \/>\n    competitors; challenges inherent in new product development, including obtaining regulatory approval; the company\u2019s<br \/>\n    ability to accurately predict future market conditions; manufacturing difficulties or delays; financial instability<br \/>\n    of international economies and sovereign risk; dependence on the effectiveness of the company\u2019s patents and other<br \/>\n    protections for innovative products; and the exposure to litigation, including patent litigation, and\/or regulatory<br \/>\n    actions.<\/p>\n<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; The company undertakes no obligation to publicly<br \/>\n    update any forward-looking statement, whether as a result of new information, future events or otherwise. Additional<br \/>\n    factors that could cause results to differ materially from those described in the forward-looking statements can be<br \/>\n    found in the company\u2019s 2020 Annual Report on Form 10-K and the company\u2019s other filings with the Securities and<br \/>\n    Exchange Commission (SEC) available at the SEC\u2019s Internet site (<a href=\"http:\/\/www.sec.gov\/\">www.sec.gov<\/a>).<\/p>\n<p style=\"text-align:center\">###<\/p>\n<p>Merck Media:<br \/>\n    <br \/>Ian McConnell<br \/>\n    <br \/>(973) 901-5722\n<\/p>\n<\/p>\n<p>Gilead Media:<br \/>\n    Marni Kottle<br \/>\n    <br \/>(650) 522-5388\n<\/p>\n<p>Merck Investor:<br \/>\n    <br \/>Peter Dannenbaum<br \/>\n    <br \/>(908) 740-1037\n<\/p>\n<p>Gilead Investor:<br \/>\n    <br \/>Jacquie Ross<br \/>\n    <br \/>(650) 358-1054\n<\/p>\n<p>Source: Merck &amp; Co., Inc.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Collaboration to Focus on Oral and Injectable Formulations of Lenacapavir and Islatravir Agreement Brings Together Potentially Complementary Medicines in Late-Stage Development with the Goal to Provide Innovative, Long-Acting Treatments in HIV Foster City, Calif. and Kenilworth N.J. \u2013 March 15, 2021 \u2013 Gilead Sciences, Inc. (Nasdaq: GILD) and Merck (NYSE: MRK), known as MSD outside the United States and Canada, today announced that they have entered into an agreement to co-develop and co-commercialize long-acting treatments in HIV that combine Gilead\u2019s investigational capsid inhibitor, lenacapavir, and Merck\u2019s investigational nucleoside reverse transcriptase translocation inhibitor, islatravir, into a two-drug regimen with the potential to provide new, meaningful treatment options for people living with HIV. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Islatravir and lenacapavir are both potentially first-in-class medicines in late-stage clinical trials, with<\/p>\n","protected":false},"template":"","meta":{"_acf_changed":false,"bdl_company_name":[],"bdl_item_external_link":[],"inpsyde_pem_expiration_date":[],"inpsyde_pem_expiration_action":[],"footnotes":""},"tags":[53,289],"class_list":["post-2776316","news_item","type-news_item","status-publish","hentry","tag-corporate-news","tag-press-release"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.9.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Gilead and Merck Announce Agreement to Jointly Develop and Commercialize Long-Acting, Investigational Treatment Combinations of Lenacapavir and Islatravir in HIV - Merck.com<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/vip2-msd.com\/merckcom-migrated\/news\/gilead-and-merck-announce-agreement-to-jointly-develop-and-commercialize-long-acting-investigational-treatment-combinations-of-lenacapavir-and-islatravir-in-hiv-2\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Gilead and Merck Announce Agreement to Jointly Develop and Commercialize Long-Acting, Investigational Treatment Combinations of Lenacapavir and Islatravir in HIV - Merck.com\" \/>\n<meta property=\"og:description\" content=\"Collaboration to Focus on Oral and Injectable Formulations of Lenacapavir and Islatravir Agreement Brings Together Potentially Complementary Medicines in Late-Stage Development with the Goal to Provide Innovative, Long-Acting Treatments in HIV Foster City, Calif. and Kenilworth N.J. \u2013 March 15, 2021 \u2013 Gilead Sciences, Inc. (Nasdaq: GILD) and Merck (NYSE: MRK), known as MSD outside the United States and Canada, today announced that they have entered into an agreement to co-develop and co-commercialize long-acting treatments in HIV that combine Gilead\u2019s investigational capsid inhibitor, lenacapavir, and Merck\u2019s investigational nucleoside reverse transcriptase translocation inhibitor, islatravir, into a two-drug regimen with the potential to provide new, meaningful treatment options for people living with HIV. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Islatravir and lenacapavir are both potentially first-in-class medicines in late-stage clinical trials, with\" \/>\n<meta property=\"og:url\" content=\"https:\/\/vip2-msd.com\/merckcom-migrated\/news\/gilead-and-merck-announce-agreement-to-jointly-develop-and-commercialize-long-acting-investigational-treatment-combinations-of-lenacapavir-and-islatravir-in-hiv-2\/\" \/>\n<meta property=\"og:site_name\" content=\"Merck.com\" \/>\n<meta property=\"article:modified_time\" content=\"2025-03-08T04:38:58+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/vip2-msd.com\/merckcom-migrated\/wp-content\/uploads\/sites\/152\/2022\/03\/Merck.png\" \/>\n\t<meta property=\"og:image:width\" content=\"3056\" \/>\n\t<meta property=\"og:image:height\" content=\"1380\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"12 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/vip2-msd.com\/merckcom-migrated\/news\/gilead-and-merck-announce-agreement-to-jointly-develop-and-commercialize-long-acting-investigational-treatment-combinations-of-lenacapavir-and-islatravir-in-hiv-2\/\",\"url\":\"https:\/\/vip2-msd.com\/merckcom-migrated\/news\/gilead-and-merck-announce-agreement-to-jointly-develop-and-commercialize-long-acting-investigational-treatment-combinations-of-lenacapavir-and-islatravir-in-hiv-2\/\",\"name\":\"Gilead and Merck Announce Agreement to Jointly Develop and Commercialize Long-Acting, Investigational Treatment Combinations of Lenacapavir and Islatravir in HIV - Merck.com\",\"isPartOf\":{\"@id\":\"https:\/\/vip2-msd.com\/merckcom-migrated\/#website\"},\"datePublished\":\"2021-03-15T06:45:00+00:00\",\"dateModified\":\"2025-03-08T04:38:58+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/vip2-msd.com\/merckcom-migrated\/news\/gilead-and-merck-announce-agreement-to-jointly-develop-and-commercialize-long-acting-investigational-treatment-combinations-of-lenacapavir-and-islatravir-in-hiv-2\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/vip2-msd.com\/merckcom-migrated\/news\/gilead-and-merck-announce-agreement-to-jointly-develop-and-commercialize-long-acting-investigational-treatment-combinations-of-lenacapavir-and-islatravir-in-hiv-2\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/vip2-msd.com\/merckcom-migrated\/news\/gilead-and-merck-announce-agreement-to-jointly-develop-and-commercialize-long-acting-investigational-treatment-combinations-of-lenacapavir-and-islatravir-in-hiv-2\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"News\",\"item\":\"https:\/\/vip2-msd.com\/merckcom-migrated\/news-archive\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Gilead and Merck Announce Agreement to Jointly Develop and Commercialize Long-Acting, Investigational Treatment Combinations of Lenacapavir and Islatravir in HIV\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/vip2-msd.com\/merckcom-migrated\/#website\",\"url\":\"https:\/\/vip2-msd.com\/merckcom-migrated\/\",\"name\":\"Merck.com\",\"description\":\"Just another vip-msd.com site\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/vip2-msd.com\/merckcom-migrated\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Gilead and Merck Announce Agreement to Jointly Develop and Commercialize Long-Acting, Investigational Treatment Combinations of Lenacapavir and Islatravir in HIV - Merck.com","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/vip2-msd.com\/merckcom-migrated\/news\/gilead-and-merck-announce-agreement-to-jointly-develop-and-commercialize-long-acting-investigational-treatment-combinations-of-lenacapavir-and-islatravir-in-hiv-2\/","og_locale":"en_US","og_type":"article","og_title":"Gilead and Merck Announce Agreement to Jointly Develop and Commercialize Long-Acting, Investigational Treatment Combinations of Lenacapavir and Islatravir in HIV - Merck.com","og_description":"Collaboration to Focus on Oral and Injectable Formulations of Lenacapavir and Islatravir Agreement Brings Together Potentially Complementary Medicines in Late-Stage Development with the Goal to Provide Innovative, Long-Acting Treatments in HIV Foster City, Calif. and Kenilworth N.J. \u2013 March 15, 2021 \u2013 Gilead Sciences, Inc. (Nasdaq: GILD) and Merck (NYSE: MRK), known as MSD outside the United States and Canada, today announced that they have entered into an agreement to co-develop and co-commercialize long-acting treatments in HIV that combine Gilead\u2019s investigational capsid inhibitor, lenacapavir, and Merck\u2019s investigational nucleoside reverse transcriptase translocation inhibitor, islatravir, into a two-drug regimen with the potential to provide new, meaningful treatment options for people living with HIV. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Islatravir and lenacapavir are both potentially first-in-class medicines in late-stage clinical trials, with","og_url":"https:\/\/vip2-msd.com\/merckcom-migrated\/news\/gilead-and-merck-announce-agreement-to-jointly-develop-and-commercialize-long-acting-investigational-treatment-combinations-of-lenacapavir-and-islatravir-in-hiv-2\/","og_site_name":"Merck.com","article_modified_time":"2025-03-08T04:38:58+00:00","og_image":[{"width":3056,"height":1380,"url":"https:\/\/vip2-msd.com\/merckcom-migrated\/wp-content\/uploads\/sites\/152\/2022\/03\/Merck.png","type":"image\/png"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"12 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/vip2-msd.com\/merckcom-migrated\/news\/gilead-and-merck-announce-agreement-to-jointly-develop-and-commercialize-long-acting-investigational-treatment-combinations-of-lenacapavir-and-islatravir-in-hiv-2\/","url":"https:\/\/vip2-msd.com\/merckcom-migrated\/news\/gilead-and-merck-announce-agreement-to-jointly-develop-and-commercialize-long-acting-investigational-treatment-combinations-of-lenacapavir-and-islatravir-in-hiv-2\/","name":"Gilead and Merck Announce Agreement to Jointly Develop and Commercialize Long-Acting, Investigational Treatment Combinations of Lenacapavir and Islatravir in HIV - Merck.com","isPartOf":{"@id":"https:\/\/vip2-msd.com\/merckcom-migrated\/#website"},"datePublished":"2021-03-15T06:45:00+00:00","dateModified":"2025-03-08T04:38:58+00:00","breadcrumb":{"@id":"https:\/\/vip2-msd.com\/merckcom-migrated\/news\/gilead-and-merck-announce-agreement-to-jointly-develop-and-commercialize-long-acting-investigational-treatment-combinations-of-lenacapavir-and-islatravir-in-hiv-2\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/vip2-msd.com\/merckcom-migrated\/news\/gilead-and-merck-announce-agreement-to-jointly-develop-and-commercialize-long-acting-investigational-treatment-combinations-of-lenacapavir-and-islatravir-in-hiv-2\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/vip2-msd.com\/merckcom-migrated\/news\/gilead-and-merck-announce-agreement-to-jointly-develop-and-commercialize-long-acting-investigational-treatment-combinations-of-lenacapavir-and-islatravir-in-hiv-2\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"News","item":"https:\/\/vip2-msd.com\/merckcom-migrated\/news-archive\/"},{"@type":"ListItem","position":2,"name":"Gilead and Merck Announce Agreement to Jointly Develop and Commercialize Long-Acting, Investigational Treatment Combinations of Lenacapavir and Islatravir in HIV"}]},{"@type":"WebSite","@id":"https:\/\/vip2-msd.com\/merckcom-migrated\/#website","url":"https:\/\/vip2-msd.com\/merckcom-migrated\/","name":"Merck.com","description":"Just another vip-msd.com site","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/vip2-msd.com\/merckcom-migrated\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"}]}},"acf":{"news_item_workflow_id":"b8cfef7e-b77d-496d-ae3f-2b8a7c637c2b","news_item_aria_label":"","media_files":null,"document_path":"https:\/\/s2.q4cdn.com\/584635680\/files\/doc_news\/Gilead-and-Merck-Announce-Agreement-to-Jointly-Develop-and-Commercialize-Long-Acting-Investigational-Treatment-Combinations-of-Lenaca-7LU3N.pdf","file":""},"_links":{"self":[{"href":"https:\/\/vip2-msd.com\/merckcom-migrated\/wp-json\/wp\/v2\/news_item\/2776316","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vip2-msd.com\/merckcom-migrated\/wp-json\/wp\/v2\/news_item"}],"about":[{"href":"https:\/\/vip2-msd.com\/merckcom-migrated\/wp-json\/wp\/v2\/types\/news_item"}],"version-history":[{"count":0,"href":"https:\/\/vip2-msd.com\/merckcom-migrated\/wp-json\/wp\/v2\/news_item\/2776316\/revisions"}],"wp:attachment":[{"href":"https:\/\/vip2-msd.com\/merckcom-migrated\/wp-json\/wp\/v2\/media?parent=2776316"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vip2-msd.com\/merckcom-migrated\/wp-json\/wp\/v2\/tags?post=2776316"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}