{"id":3663923,"date":"2025-03-07T14:11:29","date_gmt":"2025-03-07T19:11:29","guid":{"rendered":"https:\/\/vip2-msd.com\/merckcom-migrated\/?page_id=3663923"},"modified":"2025-10-14T10:10:54","modified_gmt":"2025-10-14T14:10:54","slug":"ophthalmology","status":"publish","type":"page","link":"https:\/\/vip2-msd.com\/merckcom-migrated\/research\/ophthalmology\/","title":{"rendered":"Ophthalmology"},"content":{"rendered":"\n<div id=\"mco-b2-hero-block-block_0d72d5f7e10555f1d724f69af17679a2\" class=\"mco-b2-hero-block full mccberg-block mt-2 \">\n    <div class=\"mco-b2-hero-block-wrapper\">\n        <div class=\"mco-b2-hero-block-image-section \">\n\n                            <div class=\"mco-b2-hero-block-image-container \">\n                    <picture >\n\t<source media=\"(max-width: 767px)\" data-srcset=\"https:\/\/vip2-msd.com\/merckcom-migrated\/wp-content\/uploads\/sites\/152\/2024\/11\/EyeBio_SiteImage_v1-e1731618740497.png?w=768\" srcset=\"https:\/\/vip2-msd.com\/merckcom-migrated\/wp-content\/uploads\/sites\/152\/2024\/11\/EyeBio_SiteImage_v1-e1731618740497.png?w=768\" >\n<source media=\"(min-width: 768px) and (max-width: 1199px)\" data-srcset=\"https:\/\/vip2-msd.com\/merckcom-migrated\/wp-content\/uploads\/sites\/152\/2024\/11\/EyeBio_SiteImage_v1-e1731618740497.png?h=768\" srcset=\"https:\/\/vip2-msd.com\/merckcom-migrated\/wp-content\/uploads\/sites\/152\/2024\/11\/EyeBio_SiteImage_v1-e1731618740497.png?h=768\" >\n<source media=\"(min-width: 1200px) and (max-width: 1919px)\" data-srcset=\"https:\/\/vip2-msd.com\/merckcom-migrated\/wp-content\/uploads\/sites\/152\/2024\/11\/EyeBio_SiteImage_v1-e1731618740497.png?w=1200\" srcset=\"https:\/\/vip2-msd.com\/merckcom-migrated\/wp-content\/uploads\/sites\/152\/2024\/11\/EyeBio_SiteImage_v1-e1731618740497.png?w=1200\" >\n<source media=\"(min-width: 1920px)\" data-srcset=\"https:\/\/vip2-msd.com\/merckcom-migrated\/wp-content\/uploads\/sites\/152\/2024\/11\/EyeBio_SiteImage_v1-e1731618740497.png?w=1920\" srcset=\"https:\/\/vip2-msd.com\/merckcom-migrated\/wp-content\/uploads\/sites\/152\/2024\/11\/EyeBio_SiteImage_v1-e1731618740497.png?w=1920\" >\n\t<img data-src=\"https:\/\/vip2-msd.com\/merckcom-migrated\/wp-content\/uploads\/sites\/152\/2024\/11\/EyeBio_SiteImage_v1-e1731618740497.png?w=1920\" alt=\"Medical scan of a retina showing blood vessels\" class=\"eager \" loading=\"eager\" \/>\n<\/picture>                                    <\/div>\n                        <div class=\"mco-b2-hero-block-image-container-two\">\n                            <\/div>\n        <\/div>\n\n        <div class=\"mco-b2-hero-block-content-section\">\n            <nav class=\"breadcrumbs wrapper text-descriptive\"aria-label=\"Breadcrumbs\"><\/nav>            \n                            <h1>Ophthalmology<\/h1>\n            \n                            <div class=\"mco-b2-hero-block-description\"><p style=\"text-align: left\">We\u2019re developing therapies aimed at protecting, restoring and improving vision for people living with eye diseases. Eyebiotech Limited (EyeBio) is a subsidiary of Merck and has a strong track record of developing groundbreaking therapies.<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n            \n                    <\/div>\n    <\/div>\n\n    \n<\/div>\n\n\n\n<h2 class=\"wp-block-heading has-text-align-center\">Our focus on research for retinal disease treatments<\/h2>\n\n\n<div id=\"mco-title-block-block_20a540af4deb2509d90d448c2df3eb7b\" \n\t class=\"mco-title-block mccberg-block mt-2 mb-2 aligncenter\" \n\t \t >\n\t<div class=\"wrapper\">\n\t\t<div class=\"mco-title-block-content\">\n\t\t\t\n\t\t\t<h2 class=\"mco-title-block-title\"> <\/h2>\n\n\t\t\t\t\t\t\t<p class=\"mco-title-block-description\"><p>Our team is dedicated to exploring and advancing new therapeutics for a range of retinal diseases, which remain among the most significant therapeutic challenges in ophthalmology.<\/p>\n<\/p>\n\t\t\t\t\t\t\n\t\t\t\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n<div data-type=\"multiple\" itemscope itemtype=\"https:\/\/schema.org\/FAQPage\" id=\"accordion_list_block_43464ad9776f7f09ba7990b0cb4832c4\" class=\"b6-accordion-list mccberg-block mt-2\">\n    \n    <div class=\"b6-accordion-list-block-heading\">\n        <h2>\n            <span><\/span>\n        <\/h2>\n                    <button\n                class=\"btn tertiary b6-accordion-list-toggle-expand\"\n                data-open-text=\"Expand all\"\n                data-close-text=\"Close all\"\n                aria-label=\"Expand all\"\n            >\n                <span class=\"open-text\">Expand all<\/span>\n                <span class=\"close-text\">Close all<\/span>\n            <\/button>\n            <\/div>\n\n                        <div itemscope itemprop=\"mainEntity\" itemtype=\"https:\/\/schema.org\/Question\" class=\"b6-accordion-list-item\">\n                <details  id=\"mcc_details_id_1\" class=\"b6-accordion-list-item-details\">\n                    <summary itemprop=\"name\"  class=\"b6-accordion-list-item-summary\">\n                        <h5 class= 'b6-accordion-list-item-summary-heading'>Diabetic macular edema<\/h5>                    <\/summary>\n                    <div itemscope itemprop=\"acceptedAnswer\" itemtype=\"https:\/\/schema.org\/Answer\"  class=\"b6-accordion-list-item-content\">\n                        <div itemprop=\"text\" ><p>Diabetic macular edema (DME) is a serious retinal condition that poses a risk to vision, potentially leading to blindness and a reduced quality of life if left untreated. DME impacts an estimated 750,000 people in the United States and occurs when damaged blood vessels leak into the retina, resulting in swelling in the macula, the central region of the retina crucial for precise vision necessary for everyday activities. The prevalence of DME is anticipated to rise with the increasing incidence of diabetes.<\/p>\n<\/div>\n                                            <\/div>\n                <\/details>\n                <hr \/>\n            <\/div>\n                    <div itemscope itemprop=\"mainEntity\" itemtype=\"https:\/\/schema.org\/Question\" class=\"b6-accordion-list-item\">\n                <details  id=\"mcc_details_id_2\" class=\"b6-accordion-list-item-details\">\n                    <summary itemprop=\"name\"  class=\"b6-accordion-list-item-summary\">\n                        <h5 class= 'b6-accordion-list-item-summary-heading'>Neovascular age-related macular degeneration<\/h5>                    <\/summary>\n                    <div itemscope itemprop=\"acceptedAnswer\" itemtype=\"https:\/\/schema.org\/Answer\"  class=\"b6-accordion-list-item-content\">\n                        <div itemprop=\"text\" ><p>Neovascular age-related macular degeneration (NVAMD), also known as wet age-related macular degeneration (AMD), is an advanced form of AMD that affects the macula, the central part of the retina responsible for sharp, straight-ahead vision. It is estimated that between 1 and 2 million people in the U.S. are living with NVAMD, which can impact everyday vision. This serious condition occurs when abnormal blood vessels develop beneath the retina, leaking blood or fluid into the macula, leading to rapid and severe vision loss if left untreated.<\/p>\n<\/div>\n                                            <\/div>\n                <\/details>\n                <hr \/>\n            <\/div>\n            <\/div>\n\n<div id=\"mco-title-block-block_0b9a8bd02950062e4b030aec78a1f56d\" \n\t class=\"mco-title-block mccberg-block mb-2 aligncenter\" \n\t \t >\n\t<div class=\"wrapper\">\n\t\t<div class=\"mco-title-block-content\">\n\t\t\t\n\t\t\t<h2 class=\"mco-title-block-title\">Our research efforts in retinal diseases<\/h2>\n\n\t\t\t\t\t\t\t<p class=\"mco-title-block-description\"><p>Advances in research are revealing new opportunities to translate science into solutions that serve patients with retinal diseases who have urgent and unaddressed medical needs. Our team is working to develop ophthalmology therapies by advancing research aimed at redefining the treatment of retinal diseases to help patients worldwide.<\/p>\n<\/p>\n\t\t\t\t\t\t\n\t\t\t\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n<div class=\"wp-block-columns mco-columns-wrapping is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"950\" height=\"500\" src=\"https:\/\/vip2-msd.com\/merckcom-migrated\/wp-content\/uploads\/sites\/152\/2024\/11\/Frame1_3.3_HR.jpg?w=950\" alt=\"\" class=\"wp-image-3659539\"\/><\/figure><\/div><\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Breakdown of the blood-retinal barrier and subsequent vascular leakage are hallmark features of retinal vascular diseases, such as DME and NVAMD, which result in vision loss. Vascular leakage is a modifiable feature of these diseases. Our scientists are exploring targets such as the Wingless-related integration site (Wnt) signaling pathway as research suggests it may help reduce vascular leakage and restore the integrity of the blood-retinal barrier.<\/p>\n<\/div>\n<\/div>\n\n\n\n<p class=\"has-text-align-center\"><a class=\"btn\" href=\"https:\/\/vip2-msd.com\/merckcom-migrated\/research\/product-pipeline\/\">Explore our pipeline<\/a><\/p>\n\n\n\n<div style=\"height:72px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns mco-columns-wrapping is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"300\" src=\"https:\/\/vip2-msd.com\/merckcom-migrated\/wp-content\/uploads\/sites\/152\/2024\/11\/Guyer-300x300-1.jpg?w=300\" alt=\"\" class=\"wp-image-3659541\"\/><\/figure><\/div><\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h4>\u201cWorking as one team, Merck and EyeBio are well-positioned to advance our pipeline of retinal disease candidates and help bring them to patients worldwide.&#8221;<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Dr. David R. Guyer<\/strong><br>Founder, chief executive officer and president of EyeBio<\/li>\n<\/ul>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns mco-columns-wrapping is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h4>\u201cThis acquisition allows Merck and EyeBio to work to advance a strong pipeline targeting retinal diseases. We&#8217;re committed to improving outcomes with a sharp focus on innovation in ophthalmology therapy.\u201d <\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Dr. Anthony P. Adamis<\/strong><br><strong> <\/strong>Chief scientific officer, co-founder, director &amp; chair of advisory board for EyeBio<\/li>\n<\/ul>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"300\" src=\"https:\/\/vip2-msd.com\/merckcom-migrated\/wp-content\/uploads\/sites\/152\/2024\/11\/Anthony-Adamis-300x300-1.jpg?w=300\" alt=\"\" class=\"wp-image-3659542\"\/><\/figure><\/div><\/div>\n<\/div>\n\n\n<div id=\"mco-b5-content-block-block_d85ee03338df25871415644be3d31653\"\n     class=\"mco-b5-content-block mccberg-block right\">\n    <div class=\"wrapper\">\n\t\t\t\t\t\t\t            <div class=\"mco-b5-content-block-image-section \">\n\t\t\t\t                <picture aria-label=\"Scientist reviewing test tubes\">\n                                                                        <source media=\"(max-width: 767px)\"\n                                    data-srcset=\"https:\/\/vip2-msd.com\/merckcom-migrated\/wp-content\/uploads\/sites\/152\/2020\/03\/B2-We-are-driven-by-a-shared-purpose-that-is-to_-Invent-for-Life.jpg?resize=696,425\" \/>\n                                                                                                <source media=\"(min-width: 768px) and (max-width: 1199px)\"\n                                    data-srcset=\"https:\/\/vip2-msd.com\/merckcom-migrated\/wp-content\/uploads\/sites\/152\/2020\/03\/B2-We-are-driven-by-a-shared-purpose-that-is-to_-Invent-for-Life.jpg?resize=384,468\" \/>\n                                                                                                <source media=\"(min-width: 1200px)\"\n                                    data-srcset=\"https:\/\/vip2-msd.com\/merckcom-migrated\/wp-content\/uploads\/sites\/152\/2020\/03\/B2-We-are-driven-by-a-shared-purpose-that-is-to_-Invent-for-Life.jpg?resize=750,650\" \/>\n                                                                                                <source media=\"(min-width: 1600px)\"\n                                    data-srcset=\"https:\/\/vip2-msd.com\/merckcom-migrated\/wp-content\/uploads\/sites\/152\/2020\/03\/B2-We-are-driven-by-a-shared-purpose-that-is-to_-Invent-for-Life.jpg?resize=850,744\" \/>\n                                                                                                <source media=\"(min-width: 1920px)\"\n                                    data-srcset=\"https:\/\/vip2-msd.com\/merckcom-migrated\/wp-content\/uploads\/sites\/152\/2020\/03\/B2-We-are-driven-by-a-shared-purpose-that-is-to_-Invent-for-Life.jpg?resize=980,832\" \/>\n                                                                                                <img\n                                data-src=\"https:\/\/vip2-msd.com\/merckcom-migrated\/wp-content\/uploads\/sites\/152\/2020\/03\/B2-We-are-driven-by-a-shared-purpose-that-is-to_-Invent-for-Life.jpg?resize=650,544\"\n                                alt=\"Scientist reviewing test tubes\"\n                                class=\"lazyload parallax-scroll\"\n                                loading=\"lazy\"\n                            \/>\n                                                            <\/picture>\n\t\t\t\t            <\/div>\n\t\t        <div class=\"mco-b5-content-block-content-section\">\n\t\t\t\n\t\t\t                <h3 class=\"mco-b5-content-block-heading mcc-b5-normal-title\">\n                    Merck: Who we are                <\/h3 >\n\t\t\t\n\t\t\t                <div class=\"mco-b5-content-block-description\"><p>We aspire to be the premier research-intensive biopharmaceutical company. We\u2019re at the forefront of research to deliver innovative health solutions that advance the prevention and treatment of diseases in people and animals.<\/p>\n<\/div>\n\t\t\t\n                        <div class=\"mco-b5-content-block-content-buttons-container\">\n\t\t\t\t                    <a class=\"btn secondary read_more\"\n                       href=\"https:\/\/vip2-msd.com\/merckcom-migrated\/company-overview\/\"\n                       title=\"Who we are\"\n                                              target=\"\">Who we are<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n<div class=\"mco-b5-content-block-modal popup\" style=\"display: none;\" role=\"dialog\" >\n    <div class=\"popup-wrapper\">\n        <div class=\"mco-b5-content-block-modal-content popup-content\">\n            <button class=\"mco-b5-content-block-modal-close popup-close\" >&times;<\/button>\n            <div class=\"mco-b5-content-block-modal-video\"><\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Our focus on research for retinal disease treatments Breakdown of the blood-retinal barrier and subsequent vascular leakage are hallmark features of retinal vascular diseases, such as DME and NVAMD, which result in vision loss. Vascular leakage is a modifiable feature of these diseases. Our scientists are exploring targets such as the Wingless-related integration site (Wnt) [&hellip;]<\/p>\n","protected":false},"author":64,"featured_media":0,"parent":47,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"bdl_company_name":[],"bdl_item_external_link":[],"inpsyde_pem_expiration_date":[],"inpsyde_pem_expiration_action":[],"editor_notices":[],"footnotes":""},"class_list":["post-3663923","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.9.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Ophthalmology - Merck.com<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/vip2-msd.com\/merckcom-migrated\/research\/ophthalmology\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ophthalmology - Merck.com\" \/>\n<meta property=\"og:description\" content=\"Our focus on research for retinal disease treatments Breakdown of the blood-retinal barrier and subsequent vascular leakage are hallmark features of retinal vascular diseases, such as DME and NVAMD, which result in vision loss. 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