{"id":3668130,"date":"2025-05-19T16:25:53","date_gmt":"2025-05-19T20:25:53","guid":{"rendered":"https:\/\/vip2-msd.com\/merckcom-migrated\/?post_type=story&p=3668130"},"modified":"2025-06-16T10:55:35","modified_gmt":"2025-06-16T14:55:35","slug":"were-pursuing-innovative-science-with-antibody-drug-conjugate-adc-research","status":"publish","type":"story","link":"https:\/\/vip2-msd.com\/merckcom-migrated\/stories\/were-pursuing-innovative-science-with-antibody-drug-conjugate-adc-research\/","title":{"rendered":"We’re pursuing innovative science with antibody-drug conjugate (ADC) research"},"content":{"rendered":"\n
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\n We’re pursuing innovative science with antibody-drug conjugate (ADC) research\n <\/h1>\n

Merck scientists are evaluating ADCs to explore novel treatment approaches in both solid tumors and blood cancers<\/p>\n <\/div>\n\n

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May 19, 2025<\/p>\n

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3D depiction of an antibody-drug conjugate molecule<\/em><\/p>\n\n\n\n

What are antibody-drug conjugates (ADCs)?<\/h2>\n\n\n\n

ADCs are a targeted means to transport and deliver chemotherapy to tumor cells. More than two decades since the first approval of an ADC, scientists continue to explore how, by leveraging novel scientific advancements, they can find new ways to better design and develop these molecules in order to better address current unmet needs in cancer treatment.<\/p>\n\n\n\n

ADCs are made up of three distinct yet equally important elements — an antibody, a linker and a cytotoxic drug\/chemotherapy payload. These elements work together to transport the chemotherapy payload to a specific target expressed on the surface of a cancer cell, bind to the target and then be absorbed into the cell to release the chemotherapy.<\/p>\n\n\n\n

Anatomy of an ADC<\/h2>\n\n\n\n
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